Search results for "HCN channel"

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Postsynaptic NO/cGMP Increases NMDA Receptor Currents via Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Hippocampus

2013

The nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling cascade participates in the modulation of synaptic transmission. The effects of NO are mediated by the NO-sensitive cGMP-forming guanylyl cyclases (NO-GCs), which exist in 2 isoforms with indistinguishable regulatory properties. The lack of long-term potentiation (LTP) in knock-out (KO) mice deficient in either one of the NO-GC isoforms indicates the contribution of both NO-GCs to LTP. Recently, we showed that the NO-GC1 isoform is located presynaptically in glutamatergic neurons and increases the glutamate release via hyperpolarization-activated cyclic nucleotide (HCN)-gated channels in the hippocampus. Electrophysiologi…

Patch-Clamp TechniquesCognitive NeuroscienceLong-Term PotentiationIn Vitro TechniquesNeurotransmissionNitric OxideReceptors N-Methyl-D-AspartateMiceCellular and Molecular Neurosciencechemistry.chemical_compoundCyclic nucleotidePostsynaptic potentialHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsHCN channelAnimalsAnesthetics LocalCA1 Region HippocampalCyclic GMPCyclic guanosine monophosphateMice KnockoutNeuronsbiologyLidocaineTetraethylammoniumLong-term potentiationHyperpolarization (biology)Electric StimulationPyrimidinesAnimals Newbornnervous systemchemistryGuanylate CyclaseBiophysicsbiology.proteinNMDA receptorExcitatory Amino Acid AntagonistsNeuroscienceCerebral Cortex
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